Ando K, Urano M, Koike S
Cancer Res. 1978 Jun;38(6):1769-73.
The cytostatic and cytocidal action of Corynebacterium liquefaciens was studied in a mouse squamous cell carcinoma in vivo. Kinetic analysis of tumor cells 4 and 8 days after a single i.p. dose of 2.0 mg C. liquefaciens showed a marked prolongation of the mean cell generation time (TG). This prolongation affected most the G1 and, to a lesser extent, the S phases of the cell cycle. The tumor growth factor was decreased, and the mean value of the cell loss factor was increased. Assays to determine the number of tumor cells needed to produce the tumor in one-half of the transplant recipients showed that peritoneal exudate cells collected from mice given injections of C. liquefaciens exerted tumor cell killing that depended on the peritoneal exudate cell tumor:cell ratio. This cell killing was not found with peritoneal exudate cells from normal or proteose peptone-treated mice.
在体内对小鼠鳞状细胞癌研究了液化棒状杆菌的细胞生长抑制和细胞杀伤作用。单次腹腔注射2.0mg液化棒状杆菌后4天和8天对肿瘤细胞进行动力学分析，结果显示平均细胞生成时间（TG）显著延长。这种延长对细胞周期的G1期影响最大，对S期的影响较小。肿瘤生长因子降低，细胞丢失因子的平均值增加。测定在一半移植受体中产生肿瘤所需肿瘤细胞数量的试验表明，从注射了液化棒状杆菌的小鼠收集的腹腔渗出细胞具有肿瘤细胞杀伤作用，这取决于腹腔渗出细胞与肿瘤细胞的比例。正常小鼠或经蛋白胨处理的小鼠的腹腔渗出细胞未发现这种细胞杀伤作用。
