Horiguchi Y, Furukawa F, Hamashima Y, Imamura S
Arch Dermatol Res. 1984;276(4):229-34. doi: 10.1007/BF00414233.
The MRL-lpr/lpr (MRL/l) mouse, a new animal model for the study of human systemic lupus erythematosus (SLE), shows characteristic skin manifestations in addition to several systemic autoimmune phenomena. The ultrastructural changes observed in the dermoepidermal junction (DEJ) and in the uppermost dermis were: infolding of the DEJ; deformities of the basal lamina--partial disappearance, thickening, hanging down, duplication, and separation from the basal cell membrane; basal laminalike dense material in the uppermost dermis and increased anchoring fibrils; particles composed of circulated half-desmosomes between the basal cells and the basal lamina, and in the uppermost dermis with or without an enclosing basal lamina; cell processes of the basal cells; and invagination of the basal lamina in the basal cells. Most of these findings were similar to the ultrastructural changes observed in the skin lesions of human SLE. The skin eruptions of MRL/l mice might be a new aid in the investigation of the pathogenesis of the skin lesions of human SLE.
MRL-lpr/lpr（MRL/l）小鼠是一种用于研究人类系统性红斑狼疮（SLE）的新型动物模型，除了一些系统性自身免疫现象外，还表现出特征性的皮肤表现。在真皮表皮交界处（DEJ）和最上层真皮中观察到的超微结构变化包括：DEJ折叠；基膜畸形——部分消失、增厚、下垂、重复以及与基底细胞膜分离；最上层真皮中有类似基膜的致密物质且锚定纤维增加；基底细胞与基膜之间以及最上层真皮中存在由循环半桥粒组成的颗粒，有或没有包绕的基膜；基底细胞的细胞突起；以及基底细胞中基膜的内陷。这些发现大多与人类SLE皮肤病变中观察到的超微结构变化相似。MRL/l小鼠的皮肤疹可能有助于对人类SLE皮肤病变的发病机制进行研究。
