Sassine A, Massé C, Dufour A, Hirsch J L, Cazes M, Puech P
Arch Int Pharmacodyn Ther. 1984 Jun;269(2):201-18.
The electrophysiological effects of cibenzoline on the myocardium of the anesthetized dog were studied by the endocavitary catheter method. Plasma cibenzoline levels were measured throughout. The cibenzoline effects on the sinus rate were negligible. The corrected sinus recovery time was significantly prolonged only following chronic oral administration. Atrial refractory periods were significantly increased only at the fifth minute following acute intravenous administration and after chronic oral treatment. The intranodal conduction time (AH) and the refractory periods in atrio-ventricular node were slightly modified or not at all. On the other hand, intraventricular and His-Purkinje (HV) conduction times, ventricular refractory periods and QRS duration were strongly increased following acute or chronic administration. This would imply a principal effect on the rapid kinetics sodium entry current. Nevertheless, the very marked effect upon this current could, under the experimental conditions adopted, have masked a lesser action upon other membrane permeabilities, involved in other myocardial structures.
采用心腔内导管法研究了昔苯唑啉对麻醉犬心肌的电生理效应。全程测定血浆昔苯唑啉水平。昔苯唑啉对窦性心率的影响可忽略不计。仅在长期口服给药后，校正的窦房结恢复时间显著延长。仅在急性静脉给药后第5分钟以及长期口服治疗后，心房不应期显著延长。结内传导时间（AH）和房室结不应期略有改变或未改变。另一方面，急性或慢性给药后，室内传导时间和希氏束-浦肯野纤维（HV）传导时间、心室不应期和QRS波时限显著延长。这意味着对快速动力学钠内流电流有主要作用。然而，在所采用的实验条件下，对该电流的显著作用可能掩盖了对其他心肌结构中其他膜通透性的较小作用。
