Kaplita P V, Roebuck B D
Arch Int Pharmacodyn Ther. 1984 Jun;269(2):271-6.
Proglumide (3 X 10(-4) to 3 X 10(-3) M) produced parallel rightward shifts in the cumulative concentration-response curves for cholecystokinin octapeptide (CCK-8) in the rabbit gallbladder. Contractile responses to acetylcholine and serotonin were inhibited noncompetitively by the highest concentration of proglumide tested. K+-induced contractions, however, were unaffected by proglumide. The results indicate that proglumide may be used as a selective, competitive antagonist of the actions of CCK-8 in the isolated rabbit gallbladder preparation.
丙谷胺（3×10⁻⁴至3×10⁻³M）使兔胆囊中胆囊收缩素八肽（CCK - 8）的累积浓度 - 反应曲线平行右移。在所测试的丙谷胺最高浓度下，对乙酰胆碱和5 - 羟色胺的收缩反应受到非竞争性抑制。然而，钾离子诱导的收缩不受丙谷胺影响。结果表明，丙谷胺可作为分离的兔胆囊标本中CCK - 8作用的选择性竞争性拮抗剂。
