Schiffer R B, Babigian H M
Arch Neurol. 1984 Oct;41(10):1067-9. doi: 10.1001/archneur.1984.04050210065016.
Certain CNS diseases can produce specific behavioral abnormalities. We used a computer search technique to identify all inpatients at Strong Memorial Hospital, Rochester, NY, who had received diagnoses of multiple sclerosis (MS), temporal lobe epilepsy (TLE), and amyotrophic lateral sclerosis (ALS) between 1965 and 1978. We found 368 patients with MS, 402 patients with TLE, and 124 patients with ALS. These groups were matched against the Monroe County (New York) Psychiatric Register to determine patterns of behavioral pathology. Prevalence rates for psychiatric contact were not significantly different between MS and TLE (19.3% v 22.9%), but both were higher than the prevalence rate for ALS (4.8%). When behavioral patterns were assessed, patients with MS demonstrated a significantly higher rate of depressed affective disorders (61.97% of register matches) than patients with the other two diseases. Multiple sclerosis may present a neurologic model for mood disturbance.
某些中枢神经系统疾病可导致特定的行为异常。我们采用计算机检索技术，识别了纽约州罗切斯特市斯特朗纪念医院1965年至1978年间被诊断患有多发性硬化症（MS）、颞叶癫痫（TLE）和肌萎缩侧索硬化症（ALS）的所有住院患者。我们找到了368例MS患者、402例TLE患者和124例ALS患者。将这些组与门罗县（纽约）精神病登记册进行匹配，以确定行为病理学模式。MS和TLE的精神科接触患病率无显著差异（19.3%对22.9%），但两者均高于ALS的患病率（4.8%）。在评估行为模式时，MS患者出现抑郁性情感障碍的比率（登记匹配患者的61.97%）显著高于其他两种疾病的患者。多发性硬化症可能为情绪障碍提供一种神经学模型。
