Loeffler J R, Duray P H, Sasaki C T
Arch Otolaryngol. 1984 Sep;110(9):600-3. doi: 10.1001/archotol.1984.00800350042011.
An unusual case of adult-onset lymphangioendotheliomatous macroglossia occurred in a 37-year-old woman. In addition to a dramatic acceleration of the macroglossia during her third pregnancy, the patient exacerbated the macroglossia by Valsalva's maneuvers and voluntary tongue protrusion. Bed rest and head elevation could improve the macroglossia within 24 hours. Preservation of an adequate airway during a life-threatening state of proliferation and expansion of the lymphangiomatous lesions required surgical intervention. The patient's lesion differed clinically and pathologically from usual glossal lymphangioma, hemangioma, pregnancy gingival tumor, and hemangiomatosis. Pathologically, multifocal, multicentric areas of cavernous hemangiomatouslike, cavernous lymphangiomatouslike, and angioendotheliomatous areas were present within the deep musculature of the tongue, minor salivary tissue, and soft tissue of the floor of the mouth.
一名37岁女性发生了一例罕见的成人期淋巴管内皮瘤性巨舌症。除了在她第三次怀孕期间巨舌症急剧加重外，患者通过瓦尔萨尔瓦动作和主动伸舌使巨舌症恶化。卧床休息和抬高头部可在24小时内改善巨舌症。在淋巴管瘤性病变增殖和扩张的危及生命状态下，保持气道通畅需要手术干预。患者的病变在临床和病理上与常见的舌部淋巴管瘤、血管瘤、妊娠性牙龈瘤和血管瘤病不同。病理上，在舌深部肌肉组织、小唾液腺组织和口底软组织内存在多灶性、多中心的海绵状血管瘤样、海绵状淋巴管瘤样和血管内皮瘤样区域。
