Satoh S, Shimizu Y, Maruyama Y, Ashikawa K, Isoyama S, Suzuki H, Ino-Oka E, Takishima T
Basic Res Cardiol. 1984 May-Jun;79(3):363-74. doi: 10.1007/BF01908037.
The relationship between myocardial oxygen consumption (MVO2) and left ventricular work was examined experimentally, assuming that the left ventricle is equivalent to an electrical current source generator consisting of parallel source resistance (Ri) and constant generator current (I0). The internal and external work can be calculated as (Ri X I1(2)) and (Rp X I2(2)) in this model, where I1 is current of source resistance, Rp is peripheral resistance and I2 is cardiac output. The experiments were performed with a blood-perfused isolated ejecting canine heart preparation in which the hydraulic model, simulated to an aortic input impedance, was attached to the aortic root. The peripheral resistance was changed in a stepwise fashion and left ventricular pressure, cardiac output and MVO2 were measured. The calculated total work showed a close linear correlation with the MVO2, which suggested that the left ventricle can be regarded as a current source generator and the total work as a main mechanical factor in determining the MVO2.
假设左心室等同于一个由并联源电阻（Ri）和恒定发生器电流（I0）组成的电流源发生器，通过实验研究了心肌耗氧量（MVO2）与左心室功之间的关系。在此模型中，内功和外功可分别计算为（Ri×I1²）和（Rp×I2²），其中I1为源电阻电流，Rp为外周阻力，I2为心输出量。实验采用血液灌注的离体射血犬心脏标本，在主动脉根部连接模拟主动脉输入阻抗的液压模型。逐步改变外周阻力，测量左心室压力、心输出量和MVO2。计算得到的总功与MVO2呈密切的线性相关，这表明左心室可被视为电流源发生器，而总功是决定MVO2的主要机械因素。
