Effect of linoleic acid hydroperoxide on uptake of low density lipoprotein by cultured smooth muscle cells from rabbit aorta.

The uptake of 125I-labelled low density lipoprotein by cultured smooth muscle cells from rabbit aorta was increased by linoleic acid hydroperoxide (3-6 nmol/ml); both the binding and the degradation of the low density lipoprotein were increased. These effects could be principally ascribed to the interaction of the hydroperoxide with the cells.