血小板衍生生长因子刺激原生动物四膜虫的趋化性和核酸合成。
Platelet-derived growth factor stimulates chemotaxis and nucleic acid synthesis in the protozoan Tetrahymena.
作者信息
Andersen H A, Flodgaard H, Klenow H, Leick V
出版信息
Biochim Biophys Acta. 1984 Sep 10;782(4):437-40. doi: 10.1016/0167-4781(84)90051-4.
PMID:6477920
Abstract
Platelet-derived growth factor (PDGF) is in concentrations of a few nanograms per ml a very active chemoattractant for the free-living ciliated protozoan Tetrahymena; at the same time it induces a rapid increase in incorporation of radioactive nucleic acid precursors into RNA and DNA. We find it remarkable that this lower eukaryote responds to platelet-derived growth factor in very much the same way as fibroblastic cells.
摘要
血小板衍生生长因子（PDGF）在每毫升几纳克的浓度下，对于自由生活的纤毛原生动物四膜虫是一种非常活跃的趋化因子；同时，它会促使放射性核酸前体掺入RNA和DNA的量迅速增加。我们发现这种低等真核生物对血小板衍生生长因子的反应与成纤维细胞非常相似，这很值得注意。
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