Lazzarin A, Luerti M, Uberti-Foppa C, Zavattini G, Rossi A, Tornaghi R
Biol Res Pregnancy Perinatol. 1984;5(3):130-4.
An increase in the infection rate both in mother and newborn after antenatal administration of corticosteroids for prevention of RDS has been shown. The aim of this study was to compare PMN functions in two groups of premature infants whose mothers had received betamethasone or ambroxol for prevention of RDS. Blood samples were collected within the first four days of life from 40 newborns. Thirteen infants received antenatal administration of 6 mg of betamethasone acetate and 6 mg sodium phosphate i.m., which was repeated 24 hours later. Twelve received antenatal administration of ambroxol, 1 g i.v. every day for 5 days. Fifteen did not receive any antenatal treatment. Mean gestational age and mean birth weight was not significantly different between the betamethasone group (33 +/- 3.1 weeks and 2080 +/- 567 g) and the ambroxol group (32.9 +/- 3.4 weeks and 2164 +/- 793 g). Phagocytosis and killing ability was significantly lower in the betamethasone group in comparison to the ambroxol group (21.3% +/- 2.2 rather than 48.4% +/- 15; p 0.01 and 11.4% +/- 1.7 rather than 20.5% +/- 6.1; p 0.01 respectively). Immunoglobulin or complement levels were not significantly different in the three groups.
已表明产前给予皮质类固醇预防呼吸窘迫综合征（RDS）后，母亲和新生儿的感染率均有所增加。本研究的目的是比较两组早产婴儿的多形核白细胞（PMN）功能，这两组婴儿的母亲分别接受倍他米松或氨溴索预防RDS。在出生后的头四天内从40名新生儿采集血样。13名婴儿接受了产前肌肉注射6毫克醋酸倍他米松和6毫克磷酸钠，24小时后重复一次。12名婴儿接受了产前静脉注射氨溴索，每天1克，共5天。15名婴儿未接受任何产前治疗。倍他米松组（33±3.1周，2080±567克）和氨溴索组（32.9±3.4周，2164±793克）之间的平均胎龄和平均出生体重无显著差异。与氨溴索组相比，倍他米松组的吞噬和杀伤能力显著降低（分别为21.3%±2.2而非48.4%±15；p<0.01和11.4%±1.7而非20.5%±6.1；p<0.01）。三组的免疫球蛋白或补体水平无显著差异。
