Meistrich M L
Biomed Pharmacother. 1984;38(3):137-42.
The sensitivity of cells at different stages of spermatogenesis in the mouse to various chemotherapeutic drugs will be reviewed in order to compare the actions of related drugs. The rapidly dividing differentiated spermatogonia are most sensitive to all drugs. Cells at later stages, which do not synthesize DNA but still undergo meiotic division, are most resistant. Slowly proliferating spermatogonial stem cells are of intermediate sensitivity. In general, these stem cells are most sensitive to intercalating antibiotics, less sensitive to alkylating agents, and most resistant to antimetabolites, although there are differences between agents within each group. The concept of differential sensitivity of mouse spermatogonia can be used to explain varying durations of sterility in patients treated with different chemotherapeutic drugs, but the results obtained with specific drugs in the mouse may be extrapolated directly to man.
为比较相关药物的作用，将综述小鼠精子发生不同阶段的细胞对各种化疗药物的敏感性。快速分裂的分化型精原细胞对所有药物最为敏感。后期不合成DNA但仍进行减数分裂的细胞最具抗性。缓慢增殖的精原干细胞敏感性居中。一般来说，这些干细胞对嵌入性抗生素最为敏感，对烷化剂较不敏感，对抗代谢物最具抗性，尽管每组药物之间存在差异。小鼠精原细胞的差异敏感性概念可用于解释接受不同化疗药物治疗的患者不育持续时间的差异，但在小鼠中使用特定药物获得的结果可能无法直接外推至人类。
