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大鼠苍白球损伤后行为特异性肢体使用缺陷

Behaviorally specific limb use deficits following globus pallidus lesions in rats.

作者信息

Schneider J S, Olazabal U E

出版信息

Brain Res. 1984 Aug 13;308(2):341-6. doi: 10.1016/0006-8993(84)91075-8.

DOI:10.1016/0006-8993(84)91075-8
PMID:6478211
Abstract

The effects of bilateral globus pallidus lesions were observed in rats trained to perform a somatosensory/proprioceptive guided forelimb reaching task. Postlesion reaching became very inaccurate, characterized by gross abnormalities in limb and body posture. Postural abnormalities and paw use deficits were not observed in other situations. These results suggest that pallidal damage does not result in a simple motor deficit but interferes with motor performance when movements depend upon somesthetic and proprioceptive feedback.

摘要

在经过训练以执行体感/本体感觉引导的前肢够物任务的大鼠中,观察了双侧苍白球损伤的影响。损伤后大鼠的够物动作变得非常不准确,其特征是肢体和身体姿势出现严重异常。在其他情况下未观察到姿势异常和爪子使用缺陷。这些结果表明,苍白球损伤不会导致简单的运动缺陷,而是在运动依赖于躯体感觉和本体感觉反馈时干扰运动表现。

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