Gordon M N, Finch C E
Brain Res. 1984 Aug 13;308(2):364-8. doi: 10.1016/0006-8993(84)91079-5.
The specific activities of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) were measured at neuroanatomically identified loci of the C57BL/6J mouse brain. ChAT specific activity was highest in corpus striatum. Areas of the basal forebrain had high to moderate activities, while low activities were seen in hypothalamic areas. AChE specific activity correlated highly with ChAT specific activity in all brain regions. Pronounced rostro-caudal gradients of both ChAT and AChE specific activities were discovered in the diagonal band of Broca. Overall, the regional distribution of cholinergic markers in mouse brain closely resembles that of the rat. Systemic administration of 17 beta-estradiol (E2) had no effect on ChAT or AChE specific activities in any brain region.
在C57BL/6J小鼠大脑经神经解剖学鉴定的位点测量了胆碱乙酰转移酶（ChAT）和乙酰胆碱酯酶（AChE）的比活性。ChAT比活性在纹状体中最高。基底前脑区域具有高至中等活性，而下丘脑区域活性较低。在所有脑区中，AChE比活性与ChAT比活性高度相关。在布罗卡斜带中发现了ChAT和AChE比活性明显的前后梯度。总体而言，小鼠脑中胆碱能标志物的区域分布与大鼠的非常相似。全身给予17β-雌二醇（E2）对任何脑区的ChAT或AChE比活性均无影响。
