MacKie R M, Gaukroger J M, Wilson L, Gold J
Cancer Treat Rep. 1984 Sep;68(9):1185-8.
Twenty-two patients with advanced malignant melanoma had tumor nodules biopsied and tumor cell colonies established in vitro in the colony-forming assay in the presence of vindesine. The patients then received iv vindesine at a dose of 3 mg/m2/week for 6 weeks. In four patients, in vitro death of cells exposed to vindesine in vitro correlated with clinical response to therapy. In the remaining 18 patients, lack of both in vitro and clinical response was noted.
22例晚期恶性黑色素瘤患者的肿瘤结节进行了活检，并在长春地辛存在的情况下，通过集落形成试验在体外建立了肿瘤细胞集落。然后患者接受静脉注射长春地辛，剂量为3mg/m²/周，共6周。4例患者中，体外暴露于长春地辛的细胞死亡与临床治疗反应相关。在其余18例患者中，观察到体外和临床均无反应。
