Ule G, Czernobilsky B
Clin Neuropathol. 1984 Jul-Aug;3(4):173-7.
Several multinucleated giant neurons were demonstrated in the arcuate nucleus of hypothalamus in 5 of 35 autopsied patients. In the 2 male patients, these cells showed intranuclear cytoplasmic inclusions characteristic of a persistent humoro-neural feedback effect in gonadal atrophy. Presumably, they had no pathologic effect on the neuroendocrine function of the arcuate nucleus. In the remaining 3 patients, markedly obese females, multinucleated giant neurons showed dysgenetic, dysplastic features but no evidence of feedback effect. Since severe adiposity associated with giant neurons were present in only these 3 patients, the question of a special form of hypothalamic obesity arises. Likewise, neuronal hypertrophy of the pars subventricularis of the arcuate nucleus, as demonstrated in anorexia nervosa [Hart 1971], suggests a possible participation of this nucleus in the regulation of nutrition and of body weight. Until now, it has been attributed to the ventromedial nucleus and to the lateral portions of the hypothalamus. This appears to support the proposed interpretation in our cases.
在35例尸检患者中，有5例在下丘脑弓状核发现了几个多核巨神经元。在2例男性患者中，这些细胞显示出核内胞质包涵体，这是性腺萎缩中持续体液-神经反馈效应的特征。据推测，它们对弓状核的神经内分泌功能没有病理影响。在其余3例患者中，为明显肥胖的女性，多核巨神经元表现出发育不全、发育异常的特征，但没有反馈效应的证据。由于仅在这3例患者中出现了与巨神经元相关的严重肥胖，因此出现了一种特殊形式的下丘脑性肥胖的问题。同样，如神经性厌食症中所显示的[哈特，1971年]，弓状核室周部的神经元肥大表明该核可能参与营养和体重的调节。到目前为止，这一直归因于腹内侧核和下丘脑的外侧部分。这似乎支持了我们病例中的提议解释。
