丙酮酸激酶：布氏布氏锥虫中一个受肉碱调节的ATP产生位点。

Pyruvate kinase: a carnitine-regulated site of ATP production in Trypanosoma brucei brucei.

作者信息

Gilbert R J, Klein R A

出版信息

Comp Biochem Physiol B. 1984;78(3):595-9. doi: 10.1016/0305-0491(84)90104-4.

Abstract

Pyruvate kinase activity in Trypanosoma brucei brucei is stimulated in the presence of L-carnitine and is inhibited by acetyl CoA, ATP or the ATP-Mg2+ complex. Increased pyruvate kinase activity is associated with stimulation of ATP synthesis in the presence of L-carnitine. There is evidence that carnitine stimulates pyruvate kinase activity indirectly by removing the inhibitory modulator acetyl CoA as a result of the carnitine acetyl transferase (CAT) also present in the trypanosomes.

摘要

在存在L-肉碱的情况下，布氏布氏锥虫中的丙酮酸激酶活性受到刺激，而被乙酰辅酶A、ATP或ATP-Mg2+复合物抑制。在存在L-肉碱的情况下，丙酮酸激酶活性增加与ATP合成的刺激相关。有证据表明，肉碱通过去除抑制性调节剂乙酰辅酶A间接刺激丙酮酸激酶活性，这是由于锥虫中也存在肉碱乙酰转移酶（CAT）。