Richards P
Dtsch Z Verdau Stoffwechselkr. 1984;44(4):181-3.
Interest in essential amino acid analogues developed as a means of diverting ammonia nitrogen into protein synthesis in patients with chronic renal failure, urea cycle enzyme defects and hepatic failure. Long-term practical therapeutic value has so far only been proved in children with urea cycle defects. Recent work confirms that the alpha-keto acid of leucine in particular alters protein turnover and may prove of wide practical application to improve nitrogen balance in post-operative patients and others with severe illness.
对必需氨基酸类似物的兴趣源于将氨氮转移至慢性肾衰竭、尿素循环酶缺陷及肝衰竭患者的蛋白质合成过程中。迄今为止，长期实际治疗价值仅在患有尿素循环缺陷的儿童中得到证实。近期研究证实，尤其是亮氨酸的α-酮酸可改变蛋白质周转，可能在改善术后患者及其他重症患者氮平衡方面具有广泛实际应用价值。
