[Search for cholagogic preparations in a series of heterylamide derivatives of ethylene (ethane) dicarboxylic acids].

Study of the choleretic activity of heterylamides of dicarboxylic acids has demonstrated that search for choleretic drugs in this series holds promise. The relationship of the choleretic activity and toxicity to the chemical structure of the compounds has been shown with special reference to 10 compounds--the derivatives of ethylene (ethane)-dicarboxylic acids. It has been discovered that the occurrence of the choleretic action is essentially determined by the presence in the structure of the compounds of a free cyrboxylic group. It has been also demonstrated that etherification or amidation of this group or hydrogenation of the unsaturated bond lead to the reduction or complete loss of the choleretic activity.