Iorio M A, Molinari M, Scotti de Carolis A, Niglio T
Farmaco Sci. 1984 Jul;39(7):599-611.
In order to investigate the effect of the introduction of a nitrogen atom in the alicyclic moiety of phencyclidine (PCP) a series of 1-alkyl-4-phenyl-4-(1-piperidinyl)piperidines were synthesized. The in vivo assays in mice and EEG in rabbits indicated that the presence of a second basic center in the molecule resulted in a loss of PCP-like activity. The new compounds were devoid of analgesic activity.
为了研究在苯环己哌啶（PCP）的脂环部分引入氮原子的效果，合成了一系列1-烷基-4-苯基-4-(1-哌啶基)哌啶。对小鼠的体内试验和对兔子的脑电图测试表明，分子中第二个碱性中心的存在导致了PCP样活性的丧失。这些新化合物没有镇痛活性。
