采用气液色谱法对尿液中3-乙基-5-羟基-4,5-二甲基-Δ3-吡咯啉-2-酮进行定量测定。
Quantitative determination of 3-ethyl-5-hydroxy-4,5-dimethyl-delta3-pyrrolin-2-one in urine using gas-liquid chromatography.
作者信息
Graham D J
出版信息
Clin Chim Acta. 1978 Apr 17;85(2):205-10. doi: 10.1016/0009-8981(78)90241-3.
PMID:647980
Abstract
A method is presented for the quantitation in urine of 3-ethyl-5-hydroxy-4,5-dimethyl-delta3-pyrrolin-2-one, a substance associated with hepatic porphyria and psychiatric disorders. The method involves gas-liquid chromatography following solvent extraction using one of two other heterocyclic compounds as internal standards. Quantitation of this substance in the urine of a group of normal subjects is also reported.
摘要
本文介绍了一种定量检测尿液中3-乙基-5-羟基-4,5-二甲基-δ3-吡咯啉-2-酮的方法，该物质与肝性卟啉症及精神疾病有关。该方法包括在溶剂萃取后进行气液色谱分析，使用另外两种杂环化合物中的一种作为内标。文中还报道了一组正常受试者尿液中该物质的定量检测结果。
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