日本血吸虫感染小鼠的脾脏细胞和肝脏肉芽肿自发及卵抗原诱导的免疫球蛋白和抗体合成
Spontaneous and egg antigen-induced syntheses of immunoglobulin and antibody by spleen cells and hepatic granulomas of mice infected with Schistosoma japonicum.
作者信息
Stavitsky A B, Garb K S
出版信息
Infect Immun. 1984 Oct;46(1):276-8. doi: 10.1128/iai.46.1.276-278.1984.
Abstract
In the absence of egg antigen (SEA), spleen cells from C57BL/6 mice infected for 22 weeks with Schistosoma japonicum were spontaneously induced in vitro to synthesize total immunoglobulin and antibody to SEA. Hepatic granulomas from mice infected for 12 weeks, but not for 22 weeks, also showed spontaneous syntheses of total immunoglobulin and antibody to SEA, but these syntheses were not enhanced upon the addition of SEA. Total immunoglobulin production was enhanced when SEA was added to spleen cells from mice infected for 4 to 7 weeks but not at any other time point.
摘要
在没有虫卵抗原（SEA）的情况下，感染日本血吸虫22周的C57BL/6小鼠的脾细胞在体外被自发诱导合成总免疫球蛋白和抗SEA抗体。感染12周而非22周的小鼠的肝肉芽肿也显示出总免疫球蛋白和抗SEA抗体的自发合成，但添加SEA后这些合成并未增强。当SEA添加到感染4至7周的小鼠的脾细胞中时，总免疫球蛋白产量增加，但在任何其他时间点均未增加。
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