Rarey K E, Rush N L, Davis J A, Deshmukh D R
Int J Pediatr Otorhinolaryngol. 1984 Jul;7(3):221-8. doi: 10.1016/s0165-5876(84)80002-6.
The effects of influenza B, aspirin and hyperammonemia on the functional integrity of the cochlea were examined using the ferret model for Reye's syndrome. Auditory brainstem evoked responses (ABR) were recorded from treated ferrets and compared to those recorded from controls. Delayed latencies of all waves, as well as increased I-IV Interwave latencies were observed in recordings from treated ferrets. Importantly, the latencies of Wave I, nerve generator potential from the eighth nerve, and Wave IV, response potential from the brainstem nuclei, increased on Days 3 and 5 of the study. However, recorded ABR from treated ferrets on Day 10 showed that while the latencies of Wave IV were approximate to those of controls, Wave I remained delayed. These results suggest that systemic effects of influenza B, aspirin and hyperammonemia may lead acutely to both peripheral and central auditory dysfunction, and that the functional integrity of the central auditory system may recover more quickly than that of the peripheral system. Furthermore, these results suggest that such effects may lead to acute transient hearing impairment in patients with Reye's syndrome.
利用雪貂瑞氏综合征模型，研究了乙型流感、阿司匹林和高氨血症对耳蜗功能完整性的影响。记录了经治疗雪貂的听觉脑干诱发电位（ABR），并与对照组记录的结果进行比较。在经治疗雪貂的记录中观察到所有波的潜伏期延迟，以及I-IV波间潜伏期增加。重要的是，在研究的第3天和第5天，来自第八神经的神经发生器电位I波和来自脑干核的反应电位IV波的潜伏期增加。然而，在第10天记录的经治疗雪貂的ABR显示，虽然IV波的潜伏期与对照组相近，但I波仍延迟。这些结果表明，乙型流感、阿司匹林和高氨血症的全身效应可能会急性导致外周和中枢听觉功能障碍，并且中枢听觉系统的功能完整性可能比外周系统恢复得更快。此外，这些结果表明，这种效应可能导致瑞氏综合征患者出现急性短暂性听力损害。
