Dithiocarbamato complexes of technetium: relationship between structure and hepatobiliary excretion.

A series of dithiocarbamato complexes of 99mTc have been prepared and their potential as radiopharmaceuticals investigated in mice. The complexes ranged from non-polar and colloidal to polar and completely soluble. The non-polar complexes were rapidly extracted by the liver and then only slowly excreted while the polar complexes were cleared more slowly from the blood with concurrent rapid hepatobiliary excretion.