Dambrain R, Dhem A
Int J Tissue React. 1984;6(3):275-80.
A histological and microradiographical study of thin undecalcified sections from the cranial vault of three different cases of Crouzon's disease has been performed. The fundamentally abnormal aspects of the bone tissues observed in this disease consist of a premature closing of the sutures, an external membranous bone apposition and an internal selective bone resorption leading to the production of the crests already visible in the clinical radiographs. A thickening of these crests by secondary bone apposition has been observed. The bone fragment removed in a fourth case during a second surgical treatment, when studied by the same technique, showed apparently normal bone.
对三例不同克氏综合征患者颅顶的薄脱钙切片进行了组织学和显微放射学研究。在该疾病中观察到的骨组织基本异常表现包括缝合线过早闭合、外膜骨附着以及内部选择性骨吸收，从而导致在临床X光片中已可见的嵴的形成。已观察到通过继发性骨附着使这些嵴增厚。采用相同技术对第四例患者在第二次手术治疗中切除的骨碎片进行研究时，显示其骨组织明显正常。
