Sava G, Giraldi T, Zupi G, Sacchi A
Invasion Metastasis. 1984;4(3):171-8.
The effects of 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) and its benzenoid analog p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt (DM-COOK) have been examined in mice bearing two Lewis lung carcinoma lines with different potential to spontaneously metastasize to the lungs. DTIC similarly depresses the growth of intramuscular and pulmonary tumor nodules, and also reduces the development of spontaneous lung metastases for both tumor lines. DM-COOK causes effects similar to those of DTIC on the tumor line with low metastatic potential; on the contrary, although it is highly active in inhibiting lung metastasis formation for the line with high metastatic potential, it is ineffective or marginally cytotoxic on intramuscular or on pulmonary tumor nodules, respectively. These data indicate, at least for the dimethyltriazene DM-COOK, a dissociation between sensitivity to cytotoxic and antimetastatic effects, and that tumor cell populations with a higher potential to spontaneously metastasize have a greater sensitivity to selective antimetastatic effects, concomitant with a reduced cytotoxic response to the effects of this drug.
已在携带两种具有不同自发转移至肺部潜能的Lewis肺癌细胞系的小鼠中，研究了5-(3,3-二甲基-1-三氮烯基)-咪唑-4-甲酰胺（DTIC）及其苯类类似物对-(3,3-二甲基-1-三氮烯基)苯甲酸钾盐（DM-COOK）的作用。DTIC同样会抑制肌肉内和肺部肿瘤结节的生长，并且还会减少两种肿瘤细胞系的自发肺转移。DM-COOK对低转移潜能的肿瘤细胞系产生与DTIC类似的作用；相反，尽管它在抑制高转移潜能细胞系的肺转移形成方面具有高度活性，但它对肌肉内或肺部肿瘤结节分别无效或仅有轻微的细胞毒性作用。这些数据表明，至少对于二甲基三氮烯DM-COOK而言，其细胞毒性作用和抗转移作用的敏感性之间存在分离，并且具有较高自发转移潜能的肿瘤细胞群体对选择性抗转移作用具有更高的敏感性，同时对该药物作用的细胞毒性反应降低。
