Hedlund L W, Vock P, Effmann E L, Lischko M M, Putman C E
Invest Radiol. 1984 Jul-Aug;19(4):254-62. doi: 10.1097/00004424-198407000-00004.
The computed tomographic (CT) appearance of pulmonary edema induced by elevated left atrial (LA) pressure was examined. Dogs, in the prone position, were scanned during suspended ventilation at functional residual capacity. A surgically implanted LA balloon was inflated to elevate LA pressure for 30 to 140 minutes to a mean pressure of 29.8 mm Hg. Lung water, measured gravimetrically, averaged 14.7 ml/kg body weight compared with 5.7 ml/kg in nonedema control dogs. Lung density in dogs with edema was 69.5% higher than base-line density, while in the control group final lung density was only 4% higher than base line. Analysis of regional density indicated that there were greater increases in density in more central and dependent (ventral) zones of the lung and relatively smaller increases in nondependent (dorsal) peripheral zones. These results are in contrast to the previously reported pattern of density change seen with oleic acid injury in which density increases were primarily in peripheral zones of the lung.
研究了左心房（LA）压力升高所致肺水肿的计算机断层扫描（CT）表现。将狗置于俯卧位，在功能残气量时暂停通气期间进行扫描。通过手术植入的LA球囊充气，使LA压力升高30至140分钟，平均压力达到29.8 mmHg。通过重量法测量，肺水肿狗的肺水量平均为14.7 ml/kg体重，而无水肿对照狗为5.7 ml/kg。水肿狗的肺密度比基线密度高69.5%，而对照组最终肺密度仅比基线高4%。区域密度分析表明，肺的更中央和下垂（腹侧）区域密度增加更大，而非下垂（背侧）周边区域增加相对较小。这些结果与先前报道的油酸损伤时的密度变化模式相反，在油酸损伤中，密度增加主要在肺的周边区域。
