在服用氯贝丁酯的受试者尿液中发现的两种氯贝酸（CPIB）共轭物的分离。
Separation of two conjugates of clofibric acid (CPIB) found in the urine of subjects taking clofibrate.
作者信息
Faed E M, McQueen E G
出版信息
Clin Exp Pharmacol Physiol. 1978 Mar-Apr;5(2):195-8. doi: 10.1111/j.1440-1681.1978.tb00671.x.
Abstract
- Two main conjugates of CPIB (2-[chlorophenoxy]-2-methylpropionic acid) are present in the urine of subjects taking clofibrate. The metabolites can be separated by thin-layer chromatography (TLC). 2. Both conjugates are hydrolysed by dilute alkali, but only one is hydrolysed by the enzyme beta-glucuronidase. In eighty-five urine specimens this conjugate accounted for an average of 54.5% (range 25-70%) of the total CPIB, while 2.6-12.45% (mean 5.1%) was present as free CPIB.
摘要
- 服用氯贝丁酯的受试者尿液中存在两种主要的氯贝丁酯（2-[氯苯氧基]-2-甲基丙酸）结合物。这些代谢产物可用薄层色谱法（TLC）分离。2. 两种结合物都能被稀碱水解，但只有一种能被β-葡萄糖醛酸酶水解。在85份尿液标本中，这种结合物平均占总氯贝丁酯的54.5%（范围为25%-70%），而游离氯贝丁酯占2.6%-12.45%（平均5.1%）。
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