Cavanaugh S V
J Clin Psychiatry. 1984 Oct;45(10 Pt 2):23-9.
The use of desipramine in treating major depressive disorder in the hospitalized medically ill patient is described. Desipramine has a low incidence of anticholinergic side effects, causes little orthostatic hypotension, and has a quinidine-like effect on cardiac arrhythmias. Desipramine should be used with caution in patients with risk of heart block and bundle branch block. Guidelines for administration of desipramine in the medically ill are discussed, and drug interactions with medications commonly used in this population are reviewed. Finally, the importance of providing psychotherapy along with desipramine treatment in treating the medically ill depressed patient is emphasized.
本文描述了去甲丙咪嗪在治疗内科住院的重症抑郁障碍患者中的应用。去甲丙咪嗪抗胆碱能副作用发生率低，很少引起体位性低血压，对心律失常有类似奎尼丁的作用。对于有心脏传导阻滞和束支传导阻滞风险的患者，应谨慎使用去甲丙咪嗪。讨论了在内科患者中使用去甲丙咪嗪的指南，并回顾了与该人群常用药物的药物相互作用。最后，强调了在治疗内科重症抑郁患者时，除去甲丙咪嗪治疗外提供心理治疗的重要性。
