Bender S W, Posselt H G, Stäps M, Streb H, Luang-Aroon B, Hauk H
J Pediatr Gastroenterol Nutr. 1984 Sep;3(4):506-9. doi: 10.1097/00005176-198409000-00005.
Aldolase activity with the two substrates fructose-1-phosphate and fructose-1,6-diphosphate was measured in the homogenate of small intestinal biopsy specimens from children with different malabsorptive diseases (celiac disease, cow's milk protein intolerance, infectious diarrhea, giardiasis, and Crohn's disease) and controls. It is demonstrated that the ratio of fructose-1,6-diphosphate/fructose-1-phosphate activity, which reflects the relative amounts of the crypt enzyme aldolase A (EC 4.1.2.13) and the villous enzyme aldolase B (EC 4.1.2.7), correlates very well with both the ratio of crypt to villous height (correlation factor r = 0.92) and the mitotic index (r = 0.80).
在患有不同吸收不良疾病（乳糜泻、牛奶蛋白不耐受症、感染性腹泻、贾第虫病和克罗恩病）的儿童及对照组的小肠活检标本匀浆中，测定了以果糖-1-磷酸和果糖-1,6-二磷酸这两种底物的醛缩酶活性。结果表明，反映隐窝酶醛缩酶A（EC 4.1.2.13）和绒毛酶醛缩酶B（EC 4.1.2.7）相对含量的果糖-1,6-二磷酸/果糖-1-磷酸活性比值，与隐窝与绒毛高度之比（相关系数r = 0.92）和有丝分裂指数（r = 0.80）均具有很好的相关性。
