Hennekes R, Koletzko S, Hockauf H
Klin Monbl Augenheilkd. 1984 Aug;185(2):100-4. doi: 10.1055/s-2008-1054578.
A brother and a sister with DIDMOAD syndrome (diabetes insipidus, diabetes mellitus, optic atrophy, deafness, etc.) are described. The 15-year-old girl was suffering from severe optic atrophy, severe sensorineural hearing loss but only slight diabetic retinopathy. The 16-year-old boy presented with symptoms which were the opposite: slight optic atrophy, slight sensorineural hearing loss but severe diabetic retinopathy. These complementary impairments of neuronal and (diabetic) retinal function suggest that optic atrophy and retinopathy develop independently in DIDMOAD syndrome.
本文描述了一对患有 DIDMOAD 综合征（尿崩症、糖尿病、视神经萎缩、耳聋等）的兄妹。15 岁的女孩患有严重的视神经萎缩、严重的感音神经性听力损失，但仅有轻微的糖尿病视网膜病变。16 岁的男孩则表现出相反的症状：轻微的视神经萎缩、轻微的感音神经性听力损失，但患有严重的糖尿病视网膜病变。这些神经元功能和（糖尿病性）视网膜功能的互补性损伤表明，在 DIDMOAD 综合征中，视神经萎缩和视网膜病变是独立发展的。
