Kuwamura K, McLone D G, Raimondi A J
Childs Brain. 1978;4(4):216-34. doi: 10.1159/000119779.
Obstruction of cerebrospinal fluid pathways produces changes in the parenchyma of the brain and spinal cord. A murine model of hydrocephalus (hy-3) used to study changes in the central canal of the spinal cord and these changes are correlated with events occurring in the intracranial compartment. The central canal is enlarged and subependymal interstitial edema is produced by cerebrospinal fluid at the same time as the intracranial ventricular system is expanding. Plugging of the obex results in collapse of the central canal. Ferritin tracer studies demonstrate transependymal flow of cerebrospinal fluid throughout the central canal.
脑脊液通路阻塞会导致脑和脊髓实质发生变化。一种用于研究脊髓中央管变化的脑积水小鼠模型（hy-3），这些变化与颅内腔室发生的事件相关。在颅内脑室系统扩张的同时，中央管扩大，脑脊液产生室管膜下间质水肿。闩部堵塞会导致中央管塌陷。铁蛋白示踪研究表明脑脊液在整个中央管中存在经室管膜流动。
