McDonald T J, Fox J E
Life Sci. 1984 Sep 24;35(13):1415-22. doi: 10.1016/0024-3205(84)90400-4.
The effect of GRP on the in vivo canine antrum was investigated. GRP caused a dose-dependent increase in antral gastrin output which was not significantly altered by administration of tetrodotoxin. The higher doses of GRP administered also caused excitation of antral motility which was abolished by tetrodotoxin, a finding in contrast to previous in vitro results demonstrating bombesin-induced antral smooth muscle contraction to be tetrodotoxin-resistant. These data suggest that in the in vivo canine model GRP causes antral gastrin release via non-neurally mediated mechanisms (probably by acting directly on the G-cell) and excites antral motility via neurally-mediated mechanisms.
研究了胃泌素释放肽（GRP）对犬体内胃窦的影响。GRP引起胃窦胃泌素分泌量呈剂量依赖性增加，给予河豚毒素后该增加无显著变化。给予较高剂量的GRP还引起胃窦运动兴奋，而河豚毒素可消除这种兴奋，这一发现与之前的体外实验结果相反，之前的实验表明蛙皮素诱导的胃窦平滑肌收缩对河豚毒素具有抗性。这些数据表明，在犬体内模型中，GRP通过非神经介导机制（可能是直接作用于G细胞）引起胃窦胃泌素释放，并通过神经介导机制兴奋胃窦运动。
