Koda L Y, Madamba S G, Bloom F E
Life Sci. 1984 Oct 15;35(16):1659-65. doi: 10.1016/0024-3205(84)90177-2.
The effect of disulfiram or nitrefazole pretreatment on ethanol induced hypotension was examined in urethane anesthetized rats. A relatively low dose of ethanol (150 mg/kg; i.p.) produced a characteristic hypotensive response in rats pretreated for various periods with disulfiram or nitrefazole. This hypotensive episode started 5-10 minutes following ethanol administration and lasted 40-60 minutes. The hypotensive response was not seen unless disulfiram or nitrefazole treatment preceded ethanol administration by a least 6-8 hours. The low dose of ethanol produced a plasma ethanol concentration of 10mg/100ml or less. One treatment with nitrefazole (200 mg/kg) rendered rats vulnerable to ethanol-induced hypotension for 6 but not 8 days. One treatment with disulfiram (200 mg/kg) lasted 4 but not 6 days. In addition, the hypotensive response was greater in rats treated with nitrefazole than in rats treated with an equal dose (200 mg/kg) of disulfiram.
在氨基甲酸乙酯麻醉的大鼠中研究了双硫仑或硝呋唑预处理对乙醇诱导的低血压的影响。相对低剂量的乙醇（150mg/kg；腹腔注射）在经双硫仑或硝呋唑预处理不同时间段的大鼠中产生了典型的降压反应。这种低血压发作在乙醇给药后5 - 10分钟开始，持续40 - 60分钟。除非双硫仑或硝呋唑治疗比乙醇给药至少提前6 - 8小时，否则不会出现低血压反应。低剂量的乙醇产生的血浆乙醇浓度为10mg/100ml或更低。一次硝呋唑（200mg/kg）治疗使大鼠对乙醇诱导的低血压敏感6天而非8天。一次双硫仑（200mg/kg）治疗持续4天而非6天。此外，用硝呋唑治疗的大鼠的降压反应比用等量（200mg/kg）双硫仑治疗的大鼠更大。
