Giknis M L, Damjanov I
Pharmacol Biochem Behav. 1984 Aug;21(2):317-9. doi: 10.1016/0091-3057(84)90232-6.
The duration of the loss of the righting reflex (LoRR) was measured in Swiss Webster (SW) and DBA/2 mice following intraperitoneal injection of ethanol or metronidazole alone or together. A single injection of ethanol induced to short LoRR in SW mice and a long LoRR in DBA/2 mice. Metronidazole did not induce LoRR in either strain. When the mice were exposed daily to ethanol for five days, the duration of the LoRR was prolonged in SW mice and shortened in DBA/2 mice. This indicates the development of increased neural sensitivity to ethanol in SW mice and of neural tolerance to ethanol in DBA/2 mice. The response in SW mice to administration of ethanol and metronidazole together did not differ from their response to ethanol alone. However, the duration of the LoRR in DBA/2 mice injected repeatedly with the two drugs was longer than that observed with ethanol alone. Thus metronidazole appears to inhibit the development of neural tolerance to ethanol in DBA/2 mice but has no effect on ethanol induced LoRR in SW mice.
在瑞士韦伯斯特（SW）小鼠和DBA/2小鼠腹腔注射单独或联合使用的乙醇或甲硝唑后，测量其翻正反射消失（LoRR）的持续时间。单次注射乙醇在SW小鼠中诱导出较短的LoRR，而在DBA/2小鼠中诱导出较长的LoRR。甲硝唑在这两种品系的小鼠中均未诱导出LoRR。当小鼠每天暴露于乙醇中持续五天时，SW小鼠的LoRR持续时间延长，而DBA/2小鼠的LoRR持续时间缩短。这表明SW小鼠对乙醇的神经敏感性增加，而DBA/2小鼠对乙醇产生了神经耐受性。SW小鼠对乙醇和甲硝唑联合给药的反应与其对单独乙醇给药的反应没有差异。然而，反复注射这两种药物的DBA/2小鼠的LoRR持续时间比单独使用乙醇时观察到的更长。因此，甲硝唑似乎抑制了DBA/2小鼠对乙醇的神经耐受性的发展，但对SW小鼠中乙醇诱导的LoRR没有影响。
