Hoe 263，一种具有钙通道拮抗活性的新物质。
Hoe 263, a new substance with calcium channel antagonistic activity.
作者信息
Lindner E, Ruppert D, Kaiser J
出版信息
Pharmacology. 1984;29(3):165-72. doi: 10.1159/000138008.
Hoe 263 inhibited the contraction of the potassium-depolarized pulmonary artery of the guinea pig. In this experiment it was slightly more active than verapamil. The calcium uptake of the potassium-depolarized pulmonary artery was inhibited by Hoe 263 more effectively than by prenylamine. The upstroke velocity of the potassium-depolarized papillary muscle of the guinea pig was depressed with similar concentrations of Hoe 263 and verapamil. In the (3H)-nitrendipine binding test, Hoe 263 was effective at similar concentrations as prenylamine and verapamil. The positive inotropic effect of K-strophanthin was depressed by Hoe 263 at concentrations which were comparable with those necessary for verapamil.
Hoe 263抑制豚鼠钾去极化肺动脉的收缩。在本实验中，它的活性略高于维拉帕米。Hoe 263比普尼拉明更有效地抑制钾去极化肺动脉对钙的摄取。相似浓度的Hoe 263和维拉帕米均可降低豚鼠钾去极化乳头肌的上升速度。在（3H）-尼群地平结合试验中，Hoe 263在与普尼拉明和维拉帕米相似的浓度下有效。Hoe 263在与维拉帕米所需浓度相当的浓度下可抑制毒毛花苷K的正性肌力作用。
Zotero 插件