一种新型前列腺素E1类似物（CL115,574）III. 对人体胃酸和黏液分泌的影响

A new PGE1 analogue (CL115,574) III. Effects on gastric acid and mucus secretion in man.

作者信息

Wilson D E, Levendoglu H, Adams A, Ramsamooj E

出版信息

Prostaglandins. 1984 Jul;28(1):5-11. doi: 10.1016/0090-6980(84)90109-6.

Abstract

CL115,574, an analogue of PGE1, is a potent inhibitor of gastric acid secretion in animals. The effects of this compound on gastric acid and mucus secretion were studied in 8 male volunteers. The compound was well tolerated, and its maximally effective antisecretory dose (750 micrograms) inhibited pentagastrin stimulated acid secretion by approximately 40% over a 2-hour period, with stimulation beginning one hour after the drug was orally administered. CL115,574 proved to have a significant and sustained effect upon the stimulation of mucus secretion into gastric juice. Considering the possible role that mucus may play in mucosal cytoprotection, CL115,574 because of its antisecretory and mucogenic actions may prove to be an important clinical anti-ulcer compound.

摘要

CL115574，一种前列腺素E1类似物，是一种强效的动物胃酸分泌抑制剂。在8名男性志愿者中研究了该化合物对胃酸和黏液分泌的影响。该化合物耐受性良好，其最大有效抗分泌剂量（750微克）在2小时内抑制五肽胃泌素刺激的胃酸分泌约40%，刺激在口服药物1小时后开始。CL115574被证明对刺激胃液中黏液分泌有显著且持续的作用。考虑到黏液在黏膜细胞保护中可能发挥的作用，CL115574因其抗分泌和促黏液生成作用可能被证明是一种重要的临床抗溃疡化合物。