一种新型前列腺素E2类似物（FCE 20700）对犬胃酸和胃蛋白酶分泌的影响。
The influence of a new prostaglandin E2 analogue (FCE 20700) on gastric acid and pepsin secretion in the dog.
作者信息
Soldani G, Mengozzi G, Arrigoni C, Ceserani R
出版信息
Prostaglandins Leukot Med. 1987 Jan;26(1):11-20. doi: 10.1016/0262-1746(87)90148-x.
The effects of FCE 20700, a new prostaglandin E2 analogue, on gastric acid and pepsin secretion stimulated by different secretagogues were studied in dogs. Intravenous FCE 20700 produced a significant inhibition of total acid output (TAO) induced by pentagastrin or histamine in gastric fistula (GF) dogs. This effect was short-lasting and mainly due to a reduction in the volume of gastric juice with little acid concentration change. TAO and pepsin output stimulated by 2-deoxy-D-glucose were similarly inhibited by intravenous FCE 20700. In dogs chronically fitted with both GF and Heidenhain pouch (HP), intragastric FCE 20700 significantly inhibited TAO stimulated by pentagastrin or histamine from HP, while acid secretion from GF was not significantly affected. It is concluded that FCE 20700 possesses a weak antisecretory activity in dogs. Consequently the antiulcer effects of this prostaglandin derivative seem to be largely independent from its influence on gastric acid and pepsin secretion.
在犬类中研究了新型前列腺素E2类似物FCE 20700对不同促分泌剂刺激的胃酸和胃蛋白酶分泌的影响。静脉注射FCE 20700可显著抑制胃瘘（GF）犬中由五肽胃泌素或组胺诱导的总酸排出量（TAO）。这种作用持续时间较短，主要是由于胃液量减少，而酸浓度变化不大。静脉注射FCE 20700同样抑制了2-脱氧-D-葡萄糖刺激的TAO和胃蛋白酶排出量。在长期同时植入GF和海登海因小胃（HP）的犬类中，胃内给予FCE 20700可显著抑制HP中由五肽胃泌素或组胺刺激的TAO，而GF的酸分泌未受到显著影响。结论是FCE 20700在犬类中具有较弱的抗分泌活性。因此，这种前列腺素衍生物的抗溃疡作用似乎在很大程度上与其对胃酸和胃蛋白酶分泌的影响无关。
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