丁基羟基甲苯对阿霉素诱导的大鼠皮肤坏死的保护作用。
Protective effect of butylated hydroxytoluene on adriamycin-induced skin necrosis in the rat.
作者信息
Daugherty J P, Khurana A, Simpson T A
出版信息
Res Commun Chem Pathol Pharmacol. 1984 Aug;45(2):289-92.
PMID:6484313
Abstract
The effect of butylated hydroxytoluene (BHT) on adriamycin (ADR)-induced skin ulcers was investigated using rats. The application of BHT reduced the size of the skin ulcers by the following amounts: topical application (20%); intradermal injection (50%); repeated applications of BHT (82%). Additional studies are required to determine if BHT will be a modifier of ADR extravasation in cancer patients.
摘要
使用大鼠研究了丁基化羟基甲苯（BHT）对阿霉素（ADR）诱导的皮肤溃疡的影响。BHT的应用使皮肤溃疡的大小减少了以下幅度：局部应用（20%）；皮内注射（50%）；重复应用BHT（82%）。需要进一步研究以确定BHT是否会成为癌症患者阿霉素外渗的调节剂。
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