儿童血清中的肌酸激酶同工酶——尤其关注肌酸激酶脑型同工酶（CK-BB）

Creatine kinase isoenzymes in serum from children--especially focusing on CK-BB.

作者信息

Jørgensen F B, Badskjaer J, Pedersen B S, Boysen K

出版信息

Scand J Clin Lab Invest. 1984 Sep;44(5):429-32. doi: 10.3109/00365518409083833.

Abstract

In 161 children with ages ranging from 7 months to 18 years the concentration of CK-BB in serum was measurable in 58%. The activity in serum of CK-BB (cCK-BB(S] in children varies with age and is not significantly influenced by seizure, epilepsy or body temperature. The values are most elevated during the first year of life and show a rapid fall, never reaching adult levels. Comparing mean cCK-BB(S) values in children to growth charts the resemblance is striking. CK-BB is the only CK-isoenzyme that changes with age. We postulate that cCK-BB(S) is related to growth as a physiological phenomenon. CK-MB was found in serum in 7% of the children and could not be of cardiac origin. Therefore CK-MB cannot be regarded as cardiac specific in children.

摘要

在161名年龄从7个月至18岁的儿童中，58%的儿童血清中可检测到肌酸激酶脑型同工酶（CK-BB）的浓度。儿童血清中CK-BB（cCK-BB[S]）的活性随年龄变化，不受癫痫发作、癫痫或体温的显著影响。其值在生命的第一年最高，随后迅速下降，从未达到成人水平。将儿童的平均cCK-BB[S]值与生长图表进行比较，相似性非常显著。CK-BB是唯一随年龄变化的肌酸激酶同工酶。我们推测cCK-BB[S]作为一种生理现象与生长有关。7%的儿童血清中发现了肌酸激酶同工酶MB型（CK-MB），且其并非来源于心脏。因此，CK-MB在儿童中不能被视为心脏特异性指标。