Shirley S K, Gilula L A, Siegal G P, Foulkes M A, Kissane J M, Askin F B
Skeletal Radiol. 1984;12(2):69-78. doi: 10.1007/BF00360810.
Roentgenographic review of the first 210 cases of Ewing sarcoma (ES) in the Intergroup Ewing Sarcoma Study revealed that 37.6% of cases had evidence of diffusely increased intraosseous density or diffuse sclerosis (DS). In these cases the sclerosis was usually mixed with various patterns of lysis and/or combined with a periosteal reaction. A radiograph blinded histologic review of selected biopsies showed an 83% incidence of dead bone compared to 23% in those without DS. Ten percent of the cases with DS had appositional new bone formation on dead bone whereas none of the cases without DS showed such reactions. Pathologic explanation of the roentgenographically identified diffuse sclerosis in ES has not been previously well documented in the medical literature.
对骨肉瘤研究组中最初210例尤因肉瘤（ES）病例的X线片回顾显示，37.6%的病例有骨内密度弥漫性增加或弥漫性硬化（DS）的证据。在这些病例中，硬化通常与各种溶骨模式混合和/或伴有骨膜反应。对选定活检组织进行的X线片盲法组织学检查显示，有死骨的发生率为83%，而无DS的病例为23%。有DS的病例中有10%在死骨上有贴附性新骨形成，而无DS的病例均未显示出此类反应。ES中X线片所确定的弥漫性硬化的病理学解释在医学文献中此前尚无充分记载。
