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蜥蜴肾小体的超微结构。

The ultrastructure of the renal corpuscle of a lizard.

作者信息

Gabri M S, Butler R D

出版信息

Tissue Cell. 1984;16(4):627-34. doi: 10.1016/0040-8166(84)90036-3.

DOI:10.1016/0040-8166(84)90036-3
PMID:6484943
Abstract

The few and small renal corpuscles of the lizard Podarcis (= Lacerta) taurica are composed of a tuft of three to four capillaries (glomerulus), Bowman's capsule and mesangium. The thin interdigitated capillary endothelial cells are, in most regions, in contact with the mesangium. In some regions, however, they rest on a bilaminate basement membrane with an electron-dense lamina densa and a less dense lamina rara. Bowman's capsule is composed of visceral and parietal layers. The epithelial cells (podocytes) of the visceral layer bear trabeculae connected to pedicels with microvilli. The pedicels rest on a bilaminate basement membrane which in some regions has a double-layered densa with connecting bands. Generally, this basement membrane is thicker than that of the capillary endothelial cells. The mesangium is composed mostly of irregular satellite cells with large nuclei and cytoplasmic processes, but also has smaller cells with kidney-shaped nuclei and cytoplasmic processes containing microfilaments. The mesangium cells are embedded in a collagenous matrix which extends to invade the area between the epithelial basement membrane and the capillary endothelium. These observations are discussed in relation to the structure and function of vertebrate renal corpuscles with special reference to the mesangium.

摘要

蜥蜴陶氏壁蜥(Podarcis (= Lacerta) taurica)的肾小体数量少且体积小,由一束三到四根毛细血管(肾小球)、鲍曼囊和系膜组成。在大多数区域,相互交错的薄毛细血管内皮细胞与系膜接触。然而,在某些区域,它们附着在具有电子致密致密层和较疏松的透明层的双层基底膜上。鲍曼囊由脏层和壁层组成。脏层的上皮细胞(足细胞)带有与带有微绒毛的足突相连的小梁。足突附着在双层基底膜上,在某些区域该基底膜具有带连接带的双层致密层。一般来说,这种基底膜比毛细血管内皮细胞的基底膜厚。系膜主要由具有大细胞核和细胞质突起的不规则卫星细胞组成,但也有较小的细胞,其细胞核呈肾形,细胞质突起含有微丝。系膜细胞嵌入胶原基质中,该基质延伸至侵入上皮基底膜和毛细血管内皮之间的区域。结合脊椎动物肾小体的结构和功能,特别是系膜,对这些观察结果进行了讨论。

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