口服或腹腔注射给予Fischer-344大鼠后，[14C]2,3-二氯丙烯在大鼠体内的处置情况。

Disposition of [14C]2,3-dichloropropene in Fischer-344 rats after oral or intraperitoneal administration.

作者信息

Medinsky M A, Bond J A, Dutcher J S, Birnbaum L S

出版信息

Toxicol Lett. 1984 Oct;23(1):119-25. doi: 10.1016/0378-4274(84)90017-1.

Abstract

2,3-Dichloropropene (2,3-DCP), a component of commercial fumigants and nematocides, was mixed with [14C]2,3-DCP and given to rats by peroral (p.o.) or intraperitoneal (i.p.) administration. Urine, feces, and expired air were collected over 72 h. Excretion of radioactivity in urine predominated over other routes, with 66% to 75% of the dose excreted in 72 h. Feces contained from 13% to 21% of dose. 8% of the dose was exhaled as 14CO2. At the end of 72 h, only 2% to 3% of the dose remained in the carcass with the highest concentrations of 14C in liver, kidney, testes, and lung. Approx. 91% of the p.o. dose was absorbed from the gastrointestinal (GI) tract.

摘要

2,3 - 二氯丙烯（2,3 - DCP）是商用熏蒸剂和杀线虫剂的一种成分，它与[14C]2,3 - DCP混合后经口服（p.o.）或腹腔注射（i.p.）给予大鼠。在72小时内收集尿液、粪便和呼出的气体。尿液中放射性物质的排泄量在其他排泄途径中占主导地位，72小时内排泄的剂量占66%至75%。粪便中含有剂量的13%至21%。8%的剂量以14CO2的形式呼出。在72小时结束时，仅2%至3%的剂量残留在 carcass中，肝脏、肾脏、睾丸和肺中14C的浓度最高。口服剂量中约91%从胃肠道（GI）吸收。