Tolino A, Romano L, Montemagno U
Acta Eur Fertil. 1984 May-Jun;15(3):175-7.
The authors report two cases of women with resistant ovary syndrome who were hospitalized because affected by secondary amenorrhoea. The development, in these women, of secondary sexual characteristics was normal. Neither x-ray of the sella turcica nor examination of the visual fields revealedany abnormalities. They had a normal female karyotype (46/XX). The plasmatic gonadotrophin levels, especially of FSH, were markedly raised. Administration of GnRH elicited strong responses in FSH and LH, corresponding to what is normally seen in post-menopausal women. The concentration of 17 beta-estradiol in the serum was low. The prolactin levels were normal. The patients were subjected to laparoscopy with ovarian biopsy. The ovaries were small but without morphological abnormalities. The hystological picture, similar in both ovaries, showed a cortical zone of normal appearance with an ordinary number of primordial follicles. Both patients received therapy by estrogens (epimestrol). After a period from three to seven months they showed normal ovulatory menstrual cycles. Now one of these women is pregnant.
作者报告了两例抗卵巢综合征女性病例，她们因继发性闭经而住院。这些女性的第二性征发育正常。蝶鞍的X线检查和视野检查均未发现任何异常。她们具有正常的女性核型（46，XX）。血浆促性腺激素水平，尤其是促卵泡激素（FSH）水平显著升高。给予促性腺激素释放激素（GnRH）后，FSH和促黄体生成素（LH）出现强烈反应，这与绝经后女性的正常反应一致。血清中17β-雌二醇浓度较低。催乳素水平正常。患者接受了腹腔镜卵巢活检。卵巢较小，但无形态异常。两个卵巢的组织学表现相似，皮质区外观正常，原始卵泡数量正常。两名患者均接受了雌激素（表美雌醇）治疗。三到七个月后，她们的月经周期恢复正常且有排卵。现在其中一名女性已怀孕。
