Biber B, Johannesson G, Lennander O, Martner J, Sonander H, Werner O
Acta Anaesthesiol Scand. 1984 Aug;28(4):385-9. doi: 10.1111/j.1399-6576.1984.tb02082.x.
Eight harrier dogs received an i.v. infusion of halothane dissolved 1:9 in a fat emulsion for i.v. nutrition (Intralipid, Vitrum). The rate of infusion was adjusted to maintain end-tidal halothane concentrations of 0.7% and 1.4%. At 1.4%, mean arterial pressure decreased to 76 +/- 8 mmHg (10.1 +/- 1.0 kPa) (mean +/- s.e.mean) from a pre-infusion value of 122 +/- 6 mmHg (16.2 +/- 0.8 kPa) (P less than 0.01). The concomitant decrease in cardiac output was 39% and left ventricular maximum dp/dt decreased by 50% (P less than 0.01). Changes in systemic vascular resistance and pulmonary arterial pressure were small. The haemodynamic responses during halothane inhalation, to corresponding end-tidal concentrations, were similar. Arterial and mixed venous halothane concentration increased in proportion to end-tidal concentration. There were no changes in arterial PO2 during the halothane-in-fat infusion. Triglyceride concentrations in plasma increased 12-fold. Haemodynamic recovery after the infusion was fast. We conclude that the halothane-in-fat infusion caused a dose-dependent depression of myocardial contractility and arterial pressure, similar to that seen during inhalation, and that end-tidal concentration could be used for control of the infusion rate.
八只猎兔犬接受了静脉输注，将氟烷以1:9的比例溶解于用于静脉营养的脂肪乳剂（英脱利匹特，维他美）中。调整输注速率以维持呼气末氟烷浓度为0.7%和1.4%。在1.4%的浓度时，平均动脉压从输注前的122±6 mmHg（16.2±0.8 kPa）降至76±8 mmHg（10.1±1.0 kPa）（平均值±标准误平均值）（P<0.01）。心输出量随之下降39%，左心室最大dp/dt下降50%（P<0.01）。全身血管阻力和肺动脉压变化较小。吸入氟烷期间，对相应呼气末浓度的血流动力学反应相似。动脉血和混合静脉血中的氟烷浓度与呼气末浓度成比例增加。在氟烷-脂肪乳剂输注期间，动脉血氧分压没有变化。血浆中甘油三酯浓度增加了12倍。输注后血流动力学恢复迅速。我们得出结论，氟烷-脂肪乳剂输注导致心肌收缩力和动脉压呈剂量依赖性降低，类似于吸入时所见，并且呼气末浓度可用于控制输注速率。
