肾上腺切除术及肾上腺类固醇对去甲肾上腺素合成和单胺氧化酶活性的影响。

Effects of adrenalectomy and adrenal steroids on norepinephrine synthesis and monamine oxidase activity.

作者信息

Dailey J W, Westfall T C

出版信息

Eur J Pharmacol. 1978 Apr 15;48(4):383-91. doi: 10.1016/0014-2999(78)90165-6.

Abstract

Rat heart norepinephrine (NE) tunover was increased 6--10 days after bilateral adrenalectomy. This increase was prevented by administration of deoxycorticosterone acetate (DOCA) but not by either hydrocortisone or corticosterone. Blood pressure decreased following adrenalectomy. This decrease was prevented by DOCA, hydrocortisone and corticosterone. Monoamine oxidase (MAO) activity increased in the heart but not in the liver following adrenalectomy. DOCA prevented the increase in heart MAO activity whereas hydrocortisone and corticosterone were ineffective. In intact animals, heart and liver MAO activity were not changed by 5 days of cold exposure, a procedure which increases NE turnover. It is suggested that the increase in heart NE turnover may be related to the increase in MAO activity seen after adrenalectomy.

摘要

双侧肾上腺切除术后6 - 10天，大鼠心脏去甲肾上腺素（NE）周转率增加。给予醋酸脱氧皮质酮（DOCA）可预防这种增加，但氢化可的松或皮质酮均无此作用。肾上腺切除术后血压下降。DOCA、氢化可的松和皮质酮均可预防这种下降。肾上腺切除术后，心脏中的单胺氧化酶（MAO）活性增加，而肝脏中则未增加。DOCA可预防心脏MAO活性的增加，而氢化可的松和皮质酮则无效。在完整动物中，5天的冷暴露（一种增加NE周转率的方法）不会改变心脏和肝脏的MAO活性。提示心脏NE周转率的增加可能与肾上腺切除术后MAO活性的增加有关。