Hamilton M
Acta Psychiatr Belg. 1984 May-Jun;84(3):240-8.
There is evidence from genetic and clinical studies, especially from therapeutic response to biological treatments, that endogenous or constitutional factors are important in some types of depressive illnesses. Unipolar depression is inherited differently from bipolar depression; monozygotic twins have a higher concordance rate than dizygotic twins. Endogenous depressions are cyclic in nature: the length of phases as well as the length of cycles are log-normally distributed. The effectiveness of antidepressants and ECT in endogenous depression points to a biochemical disorder. The author discusses the distinction between endogenous and exogenous depressions or between psychotic and neurotic depressions by reporting the work of Brown and others on "significant vs. stressful" events and on increased vulnerability.
来自遗传学和临床研究的证据，尤其是对生物治疗的治疗反应的证据表明，内源性或体质因素在某些类型的抑郁疾病中很重要。单相抑郁与双相抑郁的遗传方式不同；同卵双胞胎的一致性比率高于异卵双胞胎。内源性抑郁本质上是周期性的：各阶段的长度以及周期的长度呈对数正态分布。抗抑郁药和电休克疗法在内源性抑郁中的有效性表明存在生化紊乱。作者通过报告布朗等人关于“重大与应激”事件以及易感性增加的研究工作，讨论了内源性抑郁与外源性抑郁之间或精神病性抑郁与神经症性抑郁之间的区别。
