Tsujihashi H, Iguchi M, Kunikata S, Akiyama T, Kurita T
Hinyokika Kiyo. 1984 Jun;30(6):729-33.
The local renal blood flow in rabbits was determined by means of hydrogen gas clearance. Simultaneously, to clarify intrarenal redistribution during ischemic renal failure, renal vessels were occluded for some period. Namely, the rabbits were divided into three groups according to the duration of warm ischemia, which was 30, 60 and 120 minutes. The cortical and paramedullary blood flow were 215.0 +/- 29.8 and 145.6 +/- 26.3 ml/min/100 g, respectively, in the control group. In the three ischemic groups, each renal blood flow was only reduced by about 30% after 10 minutes following release of occlusion. In cases of ischemia of 30 or 60 minutes, no distinct intrarenal redistribution was seen. However, in 120 minute ischemia a slight decrement of cortical blood flow occurred after 40 minutes following release of clamp. Hydrogen gas clearance can be used to measure regional blood flow repeatedly. This method should be clinically applicable.
采用氢气清除法测定家兔局部肾血流量。同时，为阐明缺血性肾衰竭时肾内血流再分布情况，将肾血管阻断一段时间。具体而言，根据热缺血持续时间将家兔分为三组，热缺血时间分别为30分钟、60分钟和120分钟。对照组皮质和髓旁血流量分别为215.0±29.8和145.6±26.3 ml/min/100 g。在三个缺血组中，阻断解除10分钟后，各肾血流量仅减少约30%。缺血30分钟或60分钟时，未见明显的肾内血流再分布。然而，缺血120分钟时，夹闭解除40分钟后皮质血流量略有下降。氢气清除法可反复用于测量局部血流量。该方法应具有临床应用价值。
