乌拉地尔在正常血压和戈德布拉特高血压动物中的中枢和外周心血管作用。

Central and peripheral cardiovascular actions of urapidil in normotensive and Goldblatt hypertensive animals.

作者信息

Zeigler D W, Shebuski R J, Zimmerman B G

出版信息

Am J Med. 1984 Oct 5;77(4A):81-6. doi: 10.1016/s0002-9343(84)80041-8.

Abstract

The central effect of urapidil on mean arterial blood pressure, heart rate, and reflex tachycardia was studied in anesthetized normotensive and Goldblatt hypertensive dogs and anesthetized cats. The administration of 1 mg intracisternally of urapidil decreased blood pressure and heart rate in normotensive dogs, whereas 2 and 4 mg decreased heart rate and returned blood pressure to the control level. Reflex tachycardia evoked by the intravenous administration of bradykinin was suppressed in a dose-dependent manner by urapidil. In the anesthetized cat, urapidil was administered intracisternally (50 to 400 micrograms) and had no effect on heart rate. The reflex bradycardia elicited by central vagal nerve stimulation was accentuated by urapidil given intracisternally, but this only occurred in the presence of beta adrenoceptor blockade with propranolol.

摘要

在麻醉的正常血压和 Goldblatt 高血压犬以及麻醉猫中研究了乌拉地尔对平均动脉血压、心率和反射性心动过速的中枢作用。向正常血压犬脑池内注射 1 mg 乌拉地尔可降低血压和心率，而 2 mg 和 4 mg 则可降低心率并使血压恢复至对照水平。乌拉地尔以剂量依赖方式抑制静脉注射缓激肽诱发的反射性心动过速。在麻醉猫中，向脑池内注射乌拉地尔（50 至 400 微克）对心率无影响。脑池内给予乌拉地尔可增强中枢迷走神经刺激诱发的反射性心动过缓，但这仅在使用普萘洛尔进行β肾上腺素能受体阻滞的情况下发生。