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头颈部及食管手术中的微血管游离组织移植

Microvascular free tissue transfer in head and neck and esophageal surgery.

作者信息

Tabah R J, Flynn M B, Acland R D, Banis J C

出版信息

Am J Surg. 1984 Oct;148(4):498-504. doi: 10.1016/0002-9610(84)90376-3.

Abstract

Successful reconstruction for excisional defects of the head and neck and esophagus was accomplished in 93 percent of our patients using microvascular free tissue transfer. Complete failure occurred in 7 percent of the patients. Major defects after head and neck cancer surgery constituted the main indication for use of microvascular free tissue transfer for reconstruction. Ninety-four percent of the patients had undergone an extensive excisional procedure. A wide range of cutaneous, myocutaneous, and osteocutaneous free flaps, as well as free bowel autotransfers were used. Complete failure was three times higher in the previously irradiated patients (4 of 41 patients) compared with nonirradiated patients (1 of 34 patients). Morbidity and mortality rates were consistent with expected ranges in patients who were undergoing major head and neck resection. Donor site complications occurred in 23 percent. Thin flaps are favored for reconstruction of anterior defects in the oral cavity, whereas bulkier flaps are more suitable for deeper defects in the oropharynx and hypopharynx. The advantages are both aesthetic and functional. The free jejunal autograft is considered the reconstructive method of choice for defects produced by laryngopharyngoesophagectomy. Highly developed and sophisticated microsurgical skills continue to be the mainstay of success. The implication of free tissue transfer failure, especially for defects of the upper aerodigestive tract, are impressive in terms of morbidity, mortality, and cost. These considerations limit the application of this method of reconstruction to centers that have sophisticated and productive reconstructive surgeons with microsurgical skills.

摘要

在我们的患者中,93%使用微血管游离组织移植成功完成了头颈部和食管切除术后缺损的重建。7%的患者完全失败。头颈部癌症手术后的重大缺损是使用微血管游离组织移植进行重建的主要指征。94%的患者接受了广泛的切除手术。使用了多种皮瓣、肌皮瓣、骨皮瓣以及游离肠段自体移植。与未接受放疗的患者(34例中有1例)相比,既往接受过放疗的患者(41例中有4例)完全失败率高出三倍。发病率和死亡率与接受重大头颈部切除术的患者预期范围一致。供区并发症发生率为23%。薄皮瓣有利于口腔前部缺损的重建,而较厚的皮瓣更适合口咽和下咽的深部缺损。其优点兼具美观和功能。游离空肠自体移植被认为是喉咽食管切除术后缺损的首选重建方法。高度发达和精湛的显微外科技术仍然是成功的关键。游离组织移植失败的影响,特别是对上消化道气道缺损而言,在发病率、死亡率和成本方面都令人印象深刻。这些因素限制了这种重建方法仅适用于拥有具备显微外科技术、经验丰富且高效的重建外科医生的中心。

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