Wolf R, Wolf D, Sanbank M
Ann Allergy. 1984 Oct;53(4):355-7.
Patients with cholinergic urticaria exhibit increased hypersensitivity to cholinergic drugs. In the present study, an attempt was made to determine whether these patients would also cross-react to various neuromuscular blocking agents having structures analogous with acetylcholine. The four patients tested showed positive skin tests for D-tubocurarine at concentrations of 1/10,000. None of the 10 subjects in the control group and none of the patients with urticaria had positive responses, not even to a 10-fold higher concentration of D-tubocurarine. These findings suggest that caution should be exercised in the use of neuromuscular blocking agents in patients with cholinergic urticaria.
胆碱能性荨麻疹患者对胆碱能药物表现出更高的超敏反应。在本研究中，试图确定这些患者是否也会对具有与乙酰胆碱类似结构的各种神经肌肉阻滞剂产生交叉反应。接受测试的4名患者对浓度为万分之一的右旋筒箭毒碱皮肤试验呈阳性。对照组的10名受试者和荨麻疹患者均无阳性反应，即使是对浓度高10倍的右旋筒箭毒碱也无反应。这些发现表明，在胆碱能性荨麻疹患者中使用神经肌肉阻滞剂时应谨慎。
